2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126028
    (-)-Sotalol 30236-31-8 98.73%
    (-)-Sotalol ((R)-Sotalol) is the R-isomer of Sotalol. (-)-Sotalol is a hERG inhibitor, with a Kd of 0.60 μM. (-)-Sotalol can be used for the research of cardiac arrhythmias.
    (-)-Sotalol
  • HY-126179
    Fenquizone 20287-37-0 99.58%
    Fenquizone (MG-13054), a thiazide-like diuretic, exhibits chronic antihypertensive effect. Fenquizone can be used for the research of oedema and hypertension.
    Fenquizone
  • HY-12778S
    N-Demethyl Ivabradine-d6 hydrochloride ≥98.0%
    N-Demethyl Ivabradine-d6 (hydrochloride) is the deuterium labeled N-Demethyl Ivabradine, which is a metabolite of Ivabradine.
    N-Demethyl Ivabradine-d6 hydrochloride
  • HY-130419
    (±)13(14)-EpDPA 895127-64-7
    (±)13(14)-EpDPA (13,14-EpDPE) is the product of the reaction of cytochrome P-450 epoxygenase with Docosahexaenoic Acid (DHA).(±)13(14)-EpDPA has antihyperalgesic and vasorelaxative activities.
    (±)13(14)-EpDPA
  • HY-131118
    Desmethyl Ketoprofen 22071-22-3
    Desmethyl Ketoprofen has anti-inflammatory activities. Desmethyl Ketoprofen can be used for the study of angiogenesis-related disorders.
    Desmethyl Ketoprofen
  • HY-131277
    Dehydro Olmesartan 172875-98-8 99.43%
    Dehydro Olmesartan is a derivative of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.
    Dehydro Olmesartan
  • HY-131278
    Olmesartan methyl ester 1347262-29-6
    Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC50 of 66.2 μM.
    Olmesartan methyl ester
  • HY-131417
    cis-ACCP 777075-44-2
    cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases.
    cis-ACCP
  • HY-131515
    Tri-Salicylic acid 85531-17-5 98.04%
    Tri-Salicylic acid is the compound with similar properties of salicylic acid. Tri-Salicylic acid has the potential for the research of inflammation, obesity and cardiovascular diseases (extracted from patent US20170368079A1, compound III).
    Tri-Salicylic acid
  • HY-131948
    3-Chlorodiphenylamine 101-17-7 98.74%
    3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research.
    3-Chlorodiphenylamine
  • HY-13443B
    Exendin-4-Lys-azide TFA
    Exendin-4-Lys-azide TFA (Compound Ex40) is an azide derivative of Exendin-4-Lys-azide, Exendin-4, which can be used for coupling/click chemistry.
    Exendin-4-Lys-azide TFA
  • HY-134686
    Edoxaban impurity 4 480452-36-6 99.08%
    Edoxaban impurity 4 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention.
    Edoxaban impurity 4
  • HY-135121
    Ethacizine hydrochloride 57530-40-2 98.45%
    Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction.
    Ethacizine hydrochloride
  • HY-135281
    CYP11B2-IN-1 1356479-78-1 99.83%
    CYP11B2-IN-1 is a CYP11B2 inhibitor with an IC50 of 2.3 nM. CYP11B2-IN-1 inhibits CYP11B1 with an IC50 of 142 nM.
    CYP11B2-IN-1
  • HY-135363
    Valsartan Ethyl Ester 1111177-30-0 99.67%
    Valsartan Ethyl Ester is an impurity of Valsartan. Valsartan is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.
    Valsartan Ethyl Ester
  • HY-135380
    Atorvastatin acetonide tert-butyl ester 125971-95-1 99.94%
    Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
    Atorvastatin acetonide tert-butyl ester
  • HY-135383
    (3S,5S)-Pitavastatin calcium 254452-92-1 99.94%
    (3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin Calcium (HY-B0144). Pitavastatin Calcium is a potent HMG-CoA reductase inhibitor that can be used for the study of cardiovascular disease.
    (3S,5S)-Pitavastatin calcium
  • HY-135384
    tert-Buthyl Pitavastatin 586966-54-3 98.46%
    tert-Buthyl Pitavastatin is the  metabolite of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.
    tert-Buthyl Pitavastatin
  • HY-135514
    Lys-Phe 6235-35-4
    Lys-Phe is a dipeptide that inhibits both cell sickling and the gelation of solutions of sickle-cell haemoglobin.
    Lys-Phe
  • HY-135795
    1-Cyclohexyl-3-dodecyl urea 402939-18-8 ≥98.0%
    1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.
    1-Cyclohexyl-3-dodecyl urea
Cat. No. Product Name / Synonyms Application Reactivity